If you're on the political right, Orlando is an issue of Islamic terrorism.
If you're on the political left, Orlando is an issue involving the 2nd Amendment, homophobia, possible Tea Party connections, and fear of a backlash against Muslims.
Update: I definitely nailed the first two, the third was only partially a joke, and the fourth is coming any moment.
Update #2, 6/14/16: How will the reporting change if, as is now being reported in some outlets, the shooter was himself gay (you don't need to be on Jack'd or Grindr if you're going to case a nightclub)? A member of two of the left's favorite groups, will the cognitive dissonance cause heads to explode? Probably not, they'll just stick with the gun control angle.
Remember that Episcopalians, Mormons, and Catholics all have the same access to firearms in this country, and you don't hear mass murder stories about them. Just sayin'.